Bioengineering cell factories

The transition towards a clean economy requires novel processes for chemical, material, and liquid fuel production that use sustainable substrates, have improved life cycle, and hence a reduced carbon footprint. Cell factories provide the ultimate platform for this purpose to drive the world economy and mitigate risks emanating from climate change.

In this project, we use computational metabolic modeling to design novel cell factories and metabolic engineering to construct them. We aim to design cell factories which use various organic waste as a substrate to valorize it into food and feed components, but also into bio-materials and chemicals

Related publications:
  • Pinheiro MJ, Bonturi N, Belouah I, Miranda EA, Lahtvee PJ (2020). Xylose Metabolism and the Effect of Oxidative Stress on Lipid and Carotenoid Production in Rhodotorula toruloides: Insights for Future Biorefinery. Front. Bioeng. Biotechnol, DOI: 10.3389/fbioe.2020.01008
  • Lopes H.J.S., Bonturi N., Kerkhoven E.J., Miranda E.A., Lahtvee P.J. (2020). C/N ratio and carbon source-dependent lipid production profiling in Rhodotorula toruloides. Appl Microbiol Biotechnol, DOI: 10.1007/s00253-020-10386-5