During his research visit at TalTech, our partner from ALU Freiburg, Tobias Butelmann, will give a seminar (seminar room SCI-109 or online here) about living materials and the current project about Local Electron Delivery in Bioinks for Efficient Yeast Cell Factories. The seminar will be publicly available. Since this project is highly interdisciplinary, we invite all interested people to join this seminar!
Date: 06 August 2021, 11:00 – 12:00.
Abstract: The need for sustainable processes to produce value-added chemicals and materials displays a major challenge of our time. Engineered microbes have the proven power to solve these challenges, as more efficient processes are required in terms of the cell factory as well as the cultivation performance. Bioprocesses currently used in industry are primarily based on batch and fed-batch mode, where yields and productivities have peaked and require technological innovations to uplift this cap on productivities. Additive manufacturing technologies can provide opportunities to move beyond traditional processes and empower a new industrial revolution. 3D printing can be applied together with engineered microbes to print living materials with superior properties to common suspension cultures used in biorefineries. Those living materials consist of a bioink that encapsulates the host organism – a cell factory for the desired product.
One bottleneck in engineered microbes is the regeneration of co-factors, which are critical for their efficiency. To overcome this, special conductible bioinks for living materials can be designed that help embedded microbes by the delivery of electrons for co-factor regeneration. The successful implementation of such a platform has the potential to increase the efficiency of engineered microbes by multiples and, hence, create sustainable biorefinery processes.
This project of the Baltic-German University Liaison Office is supported by the German Academic Exchange Service (DAAD) with funds from the Foreign Office of the Federal Republic Germany.